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Table 6 Undesirable Effects System Organ Class Frequency Adverse Reaction Infections and Very common Respiratory tract infections (including decrease and infestations* upper respiratory tract an infection, pneumonia, sinusitis, pharyngitis, nasopharyngitis and pneumonia herpes viral) Common Systemic infections (together with sepsis, candidiasis and influenza), intestinal infections (including gastroenteritis viral), skin and gentle tissue infections (including paronychia, cellulitis, impetigo, necrotising fasciitis and herpes zoster), ear infections, oral infections (together with herpes simplex, oral herpes and tooth infections), reproductive tract infections (including vulvovaginal mycotic an infection), urinary tract infections (together with pyelonephritis), fungal infections, joint infections a hundred and sixty System Organ Class Frequency Adverse Reaction Uncommon Neurological infections (together with viral meningitis), opportunistic infections and tuberculosis (including coccidioidomycosis, histoplasmosis and mycobacterium avium advanced infection), bacterial infections, eye infections, diverticulitis1) Neoplasms benign, Common Skin most cancers excluding melanoma (including malignant and unspecified basal cell carcinoma and squamous cell (including cysts and carcinoma), polyps)* benign neoplasm Uncommon Lymphoma**, stable organ neoplasm (including breast cancer, lung neoplasm and thyroid neoplasm), melanoma** Rare Leukaemia1) Not recognized Hepatosplenic T-cell lymphoma1) Merkel cell carcinoma (neuroendocrine carcinoma of the pores and skin)1) Blood and the lymphatic Very widespread Leukopenia (including neutropenia and system problems* agranulocytosis), anaemia Common Leucocytosis, thrombocytopenia Uncommon Idiopathic thrombocytopenic purpura Rare Pancytopenia Immune system disorders* Common Hypersensitivity, allergy symptoms (including seasonal allergy) Uncommon Sarcoidosis1), vasculitis Rare Anaphylaxis1) Metabolism and nutrition Very common Lipids elevated issues 161 System Organ Class Frequency Adverse Reaction Common Hypokalaemia, uric acid elevated, blood sodium irregular, hypocalcaemia, hyperglycaemia, hypophosphatemia, dehydration Psychiatric problems Common Mood alterations (together with depression), anxiousness, insomnia Nervous system issues* Very frequent Headache Common Paraesthesias (including hypoesthesia), migraine, nerve root compression Uncommon Cerebrovascular accident1), tremor, neuropathy Rare Multiple sclerosis, demyelinating problems. 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