Astroglial cells, or astrocytes, encompass various parts of the cerebral endothelium and play a important position in regulating perfusion 7, 28], and blood brain barrier operate 9]. Astrocytes are capable of mediating several immunological/inflammatory effects. Expression of various toll like receptors (TLR) on astrocytes endows the flexibility to acknowledge not solely bacterial and viral signals but also endogenous "danger" alerts equivalent to heat shock proteins, fibrinogen degradation merchandise, and free DNA 0]. Physiologically, astrocytes play an important protective role against infection, generating inflammatory cytokines corresponding to TNF-alpha, IL-1beta, and IL-6 1]. Through secretion of various chemokines resembling CXCL10, CCL2 and BAFF, astrocytes play an important role in shaping adaptive immune responses in the CNS 2]. Astrocytes have antigen presenting capabilities and have been demonstrated to activate T and B cell responses towards exogenous and endogenous antigens 3, 34]. Although astrocytes play a critical role towards CNS infection, these cells also have potential to trigger damage to the host when functioning in an aberrant manner. For example, varied neurological diseases are related to astrocyte overproduction of inflammatory agents, which causes neural malfunction or loss of life. In amyotrophic lateral sclerosis (ALS), astrocyte secretion of a soluble neurotoxic substance has been demonstrated to be concerned in illness development 5, 36]. Astrocyte hyperactivation has been demonstrated on this illness by imaging, in addition to autopsy research 7-39]. In multiple sclerosis, astrocytes play a key position in maintaining autoreactive responses and pathological plaque formation 0, 41]. In stroke, activated astrocytes contribute to opening of the blood mind barrier 2], as well as secrete varied neurotoxic substances that contribute to post infarct neural harm 3, 44].